Brief Key Findings

Regulatory T (Treg) cells inhibit non-B non-T colitis (2001)
Gut bacteria-triggered innate immunity is sufficient for malignancy (2003)
Interleukin-10-dependent immune tolerance to microbes suppresses malignancy (2003)
Enteropathogenic bacteria trigger extra-intestinal cancer (2006)
Earlier microbe exposures facilitate tolerance and prevent cancer (2006)
Feeding of sterile microbes is sufficient for immune tolerance (2010)
Adoptive transfer of tolerant immune cells increases lifespan (2010)
Gut bacteria, IL10, and mucosal immunity unify cancer with other inflammatory disorders (2010)
oral microbe therapy heals wounds 2X faster, promotes healthful aging, prevents age-associated weight gain, and may prevent some types of cancer. (2013)

Recent Presentations

2014.07.11 Invited presentation to Van Andel Institute, Origins of Cancer Conference, Gut microbes and the cancer macroenvironment, Grand Rapids, MI

2014.06.11 TMEN Steering Committee Meeting, GI tract dysbiosis and breast cancer, New York, NY

2014.04.15 Invited presentation to Wellcome Trust, Exploring Human Host-Microbiome Interactions in Health and Disease, Hinxton, Cambridge, UK

2013.07.25 Invited presentation to NIH Human Microbiome Science Conference: Vision for the Future, Bethesda, MD

2012.03.28 Invited presentation to NIEHS Directors' Meeting, Boston, MA

2012.01.27 Invited presentation to Infectious Disease Initiative, The Broad Institute, MIT, Cambridge, MA

2012.01.13 Invited presentation to Center for Environmental Health Sciences, MIT, Cambridge, MA

2011.11.05 Presentation to AACR Tumor Microenvironment, 2011 Conference, Orlando, FL

Selected Publications

recent peer-reviewed publications

47. Varian BJ, Poutahidis T, Haner G, Hardas A, Lau V, Erdman SE. (2019). Consuming cholera toxin counteracts age-associated obesity. Oncotarget, 2019; 10:5497-5509DOI: 10.18632/oncotarget.27137 PMID: 31565184; PMCID: PMC6756858.
46. Kearney SM, Gibbons SM, Erdman SE, Alm, EJ (2018). Orthogonal Dietary Niche Enables Reversible Engraftment of a Gut Bacterial Commensal. Cell Reports: Vol 24 Issue 7, 1842-1851.DOI:http://dx.doi.org/10.1016/j.celrep.2018.07.032. PMID: 30110640; PMCID: PMC6724203.
45. Erdman SE (2016). Defining Good Health. Aging: Vol 8 No 12, 3157-3158.DOI: 10.18632/aging.101154. PMID: ; PMCID: PMC5270659.
44. Erdman S and Poutahidis T. Gut microbiota modulate host immune cells in cancer development and growth. Free Radical Biology and Medicine (2016). doi: 10.1016/j.freeradbiomed.2016.11.013. PMID: 27840315; PMCID: PMC5831246.
43. Varian BJ, Poutahidis T, DiBenedictis BT, Levkovich T, Ibrahim Y, Didyk E, Shikhman L, Cheung HK, Hardas A, Ricciardi CE, Kolandaivelu K, Veenema AH, Alm EJ, Erdman SE. Microbial lysate upregulates host oxytocin. Brain Behavior & Immunity, online: j.bbi.2016.11.002doi: 10.1016/j.bbi.2016.11.002.PMID: 27825953.; PMCID: PMC5431580.
42. Erdman SE. Gut microbiota: Microbes offer engineering strategies to combat cancer. Nature Reviews Gastroenterology, nrgastro.2016.14.doi:10.1038/nrgastro.2016.14.PMID: 26860267; PMCID: .
41. Erdman SE (2016). Microbes and healthful longevity. Aging, Online ISSN: 1945-4589, Vol 8 No 5.DOI: 10.18632/aging.100969.PMID: 27223638; PMCID: PMC4931837.
40. Varian BJ, Goureshetti S, Poutahidis T, Lakritz JR, Levkovich T, Kwok C, Teliousis K, Ibrahim M, Mirabal S and Erdman SE (2016). Beneficial bacteria inhibit cachexia. OncoTarget, 5. Online ISSN: 1949-2553.DOI: 10.18632/oncotarget.7730.PMID: 26933816 ; PMCID: PMC4914249.
39. Poutahidis T, Erdman SE. Commensal bacteria modulate the tumor microenvironment. Cancer Letters, CanLet 2015.12.028.DOI: 10.1016/j.canlet.2015.12.028.PMID: 26739062; PMCID: PMC4942371.
38. Poutahidis T, Angelopoulou K, and Erdman SE. Old enemies meet new friends for colon cancer prevention. Oncoimmunology. 2015 Oct; 4(10): e1027474.doi: 10.1080/2162402X.2015.1027474. epub June 1 2015.PMID: ; PMCID: PMC4589059.
37. Erdman SE, Poutahidis T. Gut bacteria and cancer. Biochim Biophys Acta. 2015 Aug;1856(1):86-90.doi: 10.1016/j.bbcan.2015.05.007. Epub 2015 Jun 4. PMID: 26050963; PMCID: .
36. Lakritz JR, Poutahidis T, Mirabal S, Varian BJ, Levkovich T, Ibrahim YM, Ward JM, Teng EC, Fisher B, Parry N, Lesage S, Alberg N, Gourishetti S, Fox JG, Ge Z, Erdman SE. Gut bacteria require neutrophils to promote mammary tumorigenesis. Oncotarget. 2015 Apr 20;6(11):9387-96.10.18632/oncotarget.3328. PMID: 25831236; PMCID: .
35. Doulberis M, Angelopoulou K, Kaldrymidou E, Tsingotjidou A, Abas Z, Erdman SE, Poutahidis T. Cholera-toxin suppresses carcinogenesis in a mouse model of inflammation-driven sporadic colon cancer. Carcinogenesis (2015) 36 (2): 280-290.doi: 10.1093/carcin/bgu325. epub: Dec 30 2014. PMID: 25550315; PMCID: PMC4402334.
34. Poutahidis T, Varian BJ, Levkovich T, Lakritz JR, Mirabal S, Kwok C, Ibrahim YM, Kearney SM, Chatzigiagkos A, Alm EJ, Erdman SE. Dietary microbes modulate transgenerational cancer risk. Cancer Res. 2015 Feb 25. pii: canres.2732.2014. (2015).doi: 10.1158/0008-5472.CAN-14-2732.PMID: 25716681; PMCID: .
33. Ibrahim YM, Kearney SM, Levkovich T, Springer A, Mirabal S, Poutahidis T, Varian BJ, Lakritz JR, Alm EJ, Erdman SE. Maternal Gut Microbes Control Offspring Sex and Survival. J Prob Health 2:120. (2014). doi: 10.4172/2329-8901.1000120. Sept 2014.PMID: ; PMCID: .
32. Erdman SE. Microbes, Oxytocin, and Healthful Longevity. J Prob Health 2: 117 (2014). doi: 10.4172/2329-8901.1000117. Aug 2014.PMID: ; PMCID: .
31. David LA, Materna AC, Friedman J, Campos-Baptista MI, Blackburn MC, Perrotta A, Erdman SE and Alm EJ. Host lifestyle affects human microbiota on daily timescales. Genome Biology 15, no. 7 (2014): R89.doi:10.1186/gb-2014-15-7-r89. Jul 2014.PMID: 25146375; PMCID: .
30. Poutahidis T, Kleinewietfeld M, Erdman S. Gut microbiota and the paradox of cancer immunotherapy. Front. Immunol. 5:157 (2014).DOI 10.3389/fimmu.2014.00157. Mar 2014.PMID: 24778636; PMCID: PMC3985000.
29. Varian BJ, Poutahidis T, Levkovich T, Ibrahim YM, Lakritz J, Chatzigiagkos A, Scherer-Hoock A, Alm EJ, and Erdman SE. Beneficial Bacteria Stimulate Youthful Thyroid Gland Activity. J Obes Weight Loss Ther. 2014, 4:220.doi: 10.4172/2165-7904.1000220. June 2014.
28. Karamanavi K, Angelopoulou K, Lavrentiadou S, Tsingotjidou A, Abas Z, Taitzoglou I, Vlemmas I, Erdman S, and Poutahidis, T. Urokinase-Type Plasminogen Activator Deficiency Promotes Neoplasmatogenesis in the Colon of Mice. Trans. Oncology. 2014 7(2):174-185.doi: 10.1016/j.tranon.2014.0.002. June 2014.PMID: 24913672; PMCID: PMC4101295.
27. Erdman SE and Poutahidis T. Probiotic ‘glow of health’: it's more than skin deep. Beneficial Microbes 2014 May; 5(2); ISSN 1876-2891 (online). DOI 10.3920/BM2013.0042. Mar 2014.PMID: 24675231.
26. Erdman SE and Poutahidis T. The microbiome modulates the tumor macroenvironment. OncoImmunology 2014; 3:e28271.doi: 10.4161/onci.28271.PMID: 25050199 [PubMed] PMCID: PMC4063141.
25. Poutahidis T, Springer A, Levkovich T, Qi P, Varian BJ, Lakritz J, Ibrahim YM, Chatzigiagkos A, Alm EJ, and Erdman SE. Probiotic Microbes Sustain Youthful Serum Testosterone Levels and Testicular Size in Aging Mice. PLoS ONE 9(1): e84877.doi:10.1371/journal.pone.0084877. Jan 2014.PMID: 24392159; PMCID: PMC3879365.
24. Lakritz J, Poutahidis T, Levkovich T, Varian BJ, Ibrahim YM, Chatzigiagkos A, Mirabal S, Alm EJ, and Erdman SE. Beneficial bacteria stimulate host immune cells to counteract dietary and genetic predisposition to mammary cancer in mice. Int J Cancer. 10.1002/ijc.28702doi: 10.1002/ijc.28702. Dec 2013.PMID: 24382758; PMCID: PMC4131439.
23. Manzel A, Muller DN, Hafler DA, Erdman SE, Linker RA, Kleinewietfeld M. Role of "western diet" in inflammatory autoimmune diseases. Curr Allergy Asthma Rep. 2014 Jan;14(1):404.doi: 10.1007/s11882-013-0404-6. Dec 2013.PMID: 24338487; PMCID: PMC4034518.
22. Poutahidis T, Kearney SM, Levkovich T, Qi P, Varian BJ, Lakritz J, Ibrahim YM, Chatzigiagkos A, Alm EJ, and Erdman SE. Microbial symbionts accelerate wound healing via the neuropeptide hormone oxytocin. PLoS ONE 8(10): e78898.doi:10.1371/journal.pone.0078898. Oct 2013.PMID: 24205344; PMCID: PMC3813596.
21. Poutahidis T, Cappelle K, Levkovich T, Lee CW, Doulberis M, Ge Z, Fox JG, Horwitz BH, and Erdman SE. Pathogenic intestinal bacteria enhance prostate cancer development via systemic activation of immune cells in mice. PLoS ONE 8(8): e73933.doi:10.1371/journal.pone.0073933. Aug 2013.PMID: 23991210; PMCID: PMC3753256.
20. Poutahidis T, Kleinewietfeld M, Smillie C, Levkovich T, Perrotta A, Bhela S, Varian BJ, Ibrahim YM, Lakritz JR, Kearney S, Chatzigiagkos A, Hafler DA, Alm EJ, and Erdman SE. Microbial reprogramming inhibits Western diet-associated obesity. PLOS One, 8(7): e68596.doi:10.1371/journal.pone.0068596. Jul 2013.PMID: 23874682; PMCID: PMC3707834.
19. Levkovich T, Poutahidis T, Smillie C, Varian BJ, Ibrahim YM, Lakritz JR, Alm EJ, and Erdman SE. Probiotic bacteria induce a 'Glow of Health'. PLoS ONE 8(1): e53867. doi:10.1371/journal.pone.0053867. Jan 2013.PMID: 23342023; PMCID: PMC3547054.
18. Karagiannis GS, Poutahidis T, Erdman SE, Kirsch R, Riddell RH, Diamandis EP. Cancer-associated fibroblasts drive the progression of metastasis through both paracrine and mechanical pressure on cancer tissue. Mol Cancer Res. 2012 Nov;10(11):1403-18. doi: 10.1158/1541-7786.MCR-12-0307. Epub 2012 Sep 28.PMID: 23024188.
17. Erdman, SE., and T. Poutahidis. Special Section paper: Cancer inflammation and regulatory T cells. (Invited). Int J Cancer 127:768-779. 2010.PMID: 20518013; PMCID: PMC4068033.
16. Houghton JM, Li H, Fan X, Liu Y, Liu J, Rao VP, Poutahidis T, Taylor C, Jackson E, Hewes C, Lyle S, Cerny A, Bowen G, Cerny J, Moore N, Kurt-Jones EA, Erdman SE. Mutations in bone marrow derived stromal stem cells unmask latent malignancy. Stem Cells Dev, Vol. 19, No. 8, 1153-1166. 2010.doi: 10.1089/scd.2009.0439. PMID: 20199238; PMCID: PMC3135253.
15. S.E. Erdman, V. P. Rao, W. Olipitz, C. L. Taylor, E. A. Jackson, T. Levkovich, B. H. Horwitz, J. G. Fox, Z. Ge, and T. Poutahidis. Unifying roles for regulatory T cells and inflammation in cancer. Int J Cancer 126: 1651-65. 2010. doi: 10.1002/ijc.24923.PMID: 19795459; PMCID: PMC4068029.
14. Erdman SE., Poutahidis T. Roles for Inflammation and Regulatory T Cells in Colon Cancer. Toxicol Pathol Vol. 38 No. 1: 76-87. January 2010. Published online Dec 17 2009: doi: 10.1177/0192623309354110PMID: 20019355; PMCID: PMC4068028.
13. Badoual C, Hans S, Fridman WH, Brasnu D, Erdman SE, Tartour E. Revisiting the prognostic value of regulatory T cells in patients with cancer. J Clin Oncol. 2009 Jul 1: 27(19):5-6.doi: 10.1200/JCO.2009.23.0680.PMID: 19470910.
12. Erdman SE, Rao VP, Poutahidis T, Rogers AB, Taylor CL, Jackson EA, Ge Z, Lee CW, Schauer DB, Tannenbaum SR, Fox JG. Tumor necrosis factor-alpha and nitric oxide-dependent mechanisms trigger colonic inflammation and carcinogenesis in Helicobacter hepaticus-infected Rag2-deficient mice. Proc Natl Acad Sci USA 106(4):1027-1032, 2009. doi: 10.1073/pnas.0812347106.PMID: 19164562; PMCID: PMC2633549.
11. Poutahidis T., VP Rao, W Olipitz, CL Taylor, EA Jackson, TLevkovich, CW Lee, JG Fox, Z Ge, and SE Erdman. CD4+ Lymphocytes Modulate Prostate Cancer Progression in Mice. Intl J Cancer 15: 125(4):868-78, 2009. doi: 10.1002/ijc.24452.PMID: 19408303.
10. Watanabe K, Rao VP, Poutahidis T, Rickman BH, Ohtani M, Xu S, Rogers AB, Ge Z, Horwitz BH, Fujioka T, Erdman SE, Fox JG. CLTA-4 blockade abrogates protection by regulatory T cells in a mouse model of microbially-induced colitis. Infect Immun 76:5834-5842, 2008. doi: 10.1128/IAI.00542-08.PMID: 18824539.
9. Gounaris E, Erdman SE, Restaino C, Gurish MF, Friend DS, Gounari F, Lee DM, Zhang G, Glickman JN, Shin K, Rao VP, Poutahidis T, Weissleder R, McNagny KM, Khazaie K. Mast cells are an essential hematopoietic component for polyp development. Proc Natl Acad Sci. 2007 Dec 11: 104(50):1977-82. Epub 2007 Dec 6.2007 Dec 11;104(50):19977-82.PMID: 18077429; PMCID: PMC2148408.
8. Poutahidis T, Haigis KM, Rao VP, Nambiar PR, Taylor CL, Ge Z,Watanabe K, Davidson A, Horwitz BH, Fox JG, Erdman SE. Rapid reversal of interleukin-6-dependent epithelial invasion in microbially induced colon carcinoma. Carcinogenesis 28:2614-2623, 2007. 2007 Dec;28(12):2614-23.PMID: 17724375.
7. Rao VP, Poutahidis T, Fox JG, and SE Erdman. Breast Cancer: should gastrointestinal bacteria be on our radar screen? Cancer Res 67:3, 2007. (invited review).DOI: 10.1158/0008-5472.CAN-06-3468. 2007 Feb 1;67(3):847-50.PMID: 17283110.
6. Rao VP, Poutahidis T, Ge Z, Nambiar PR, Horwitz BH, Fox JG, Erdman SE. Pro-inflammatory CD4+CD45RBhi lymphocytes promote mammary and intestinal carcinogenesis in ApcMin/+ mice. Cancer Res 66 :57-61, 2006.2006 Jan 1;66(1):57-61.PMID: 16397216.
5. Rao VP, Poutahidis T, Ge Z, Nambiar PR, Boussahmain C, Wang YY, Horwitz BH, FoxJG, Erdman SE. Innate immune inflammatory response against enteric bacteria Helicobacter hepaticus induces mammary adenocarcinoma in mice. Cancer Res 66: 7395-7400, 2006.2006 Aug 1;66(15):7395-400.PMID: 16885333.
4. Erdman SE, Sohn JJ, Rao VP, Nambiar PR, Ge Z, Fox JG, Schauer DB. CD4+CD25+ regulatory lymphocytes induce regression of intestinal tumors in ApcMin/+ mice. Cancer Res 65: 3998‐4004, 2005. 2005 May 15;65(10):3998-4004.PMID: 15899788.
3. Erdman SE, Rao VP, Poutahidis T, Ge Z, Feng Y, Tomczak M, Rogers AB, Horwitz BH, Fox JG. CD4+CD25+ regulatory lymphocytes require interleukin 10 to interrupt colon carcinogenesis in mice. Cancer Res 63: 6042‐6050, 2003.2003 Sep 15;63(18):6042-50.PMID: 14522933.
2. Erdman SE, Poutahidis T, Rogers AB, Tomczak M,Cormier K, Horwitz BH, Fox JG. CD4+ CD45Rblo regulatory T lymphocytes inhibit microbially‐induced colon cancer in Rag2‐deficient mice. Am J Path 162: 691‐702, 2003. 2003 Feb;162(2):691-702.PMID: 12547727; PMCID: PMC1851156.
1. Erdman SE, Fox JG, Sheppard BJ, Feldman D, Horwitz BH. Regulatory T cells prevent non-B non-T colitis. Gastroenterology. 2001;120(Suppl 1):A524. DOI: 10.1016/S0016-5085(08)82601-7.

patents

United States of America Serial No. 11/598002, Filed November 13, 2006, "Interleukin-10 Compositions For The Treatment Of Adenocarcinomas" by Anne Davidson, Susan E. Erdman, James G. Fox and Bruce Horwitz